Fred Nijhout's Lab Page

Department of Biology

Duke University




Nijhout HF, Grunert LW. The cellular and physiological mechanism of wing-body scaling in Manduca sexta.. Science 330: 1693-1695 (2010).

Tobler A, Nijhout HF. Developmental constraints on the evolution of wing-body allometry in Manduca sexta. Evolution & Development 12: 57-66 (2010).

Nijhout HF. Molecular and physiological basis of colour pattern formation. Advances in Insect Physiology. 38: 219-265 (2010).

Best J, Nijhout HF, Reed M. Serotonin synthesis, release and reuptake in terminals: a mathematical model. Theoretical Biology and Medical Modelling. 7: 34ff (2010)

Reed MC, Lieb A, Nijhout HF. The biological significance of substrate inhibition: A mechanism with diverse functions. BioEssays 32: 422-429 (2010).

Tobler A, Nijhout HF. A switch in the control of growth of the wing imaginal disks of Manduca sexta. PLoS-One 5(5): e10723 (2010).

Best J, Reed M, Nijhout HF. Models of dopaminergic and serotonergic signaling. Pharmacopsychiatry 43: S61-S66 (2010).

Diamond SE, Hawkins SD, Nijhout HF, Kingsolver, JG. Evolutionary divergence of field and laboratory populations of Manduca sexta in response to host-plant quality. Ecological Entomology 35: 166-174 (2010).

Nijhout HF, Roff DA, Davidowitz G. Conflicting processes in the evolution of body size and development time. Philosophical Transactions of the Royal Society B-Biological Sciences. 365: 567-575 (2010).

Bowsher JH, Nijhout HF. Partial co-option of the appendage patterning pathway in the development of abdominal appendages in the sepsid fly Themira biloba. Development Genes and Evolution 219: 577-587 (2010).

Thomas DC, Conti DV, Baurley J, Nijhout HF, Reed MC, and Ulrich CM. Use of pathway information in molecular epidemiology. Human Genomics 4: 21-42 (2009).

Nijhout HF, Gregory JF, Fitzpatrick C1, Cho E, Lamers KY, Ulrich CM, Reed MC. A mathematical model gives insights into the effects of vitamin B-6 deficiency on 1-carbon and glutathione metabolism. Journal of Nutrition 139: 784-791 (2009).

Howell AS, Savage NS, Johnson SA, Bose I, Wagner AW, Zyla TR, Nijhout HF, Reed MC, Goryachev AB and Lew DJ. Singularity in polarization: Rewiring yeast cells to make two buds. Cell 139: 731-743 (2009).

Nijhout HF and Suzuki, Y. Environment and genetic accommodation. Biological Theory 3:1-9 (2009).

Best JA, Nijhout HF, Reed MC. Homeostatic mechanisms in dopamine synthesis and release: a mathematical model. Theoretical Biology and Medical Modelling 6:21 (2009) .

Reed M, Best J, Nijhout HF. Passive and active stabilization of dopamine in the striatum. Bioscience Hypotheses 2: 240-244 (2009).

Suzuki Y, Nijhout HF. Constraint and developmental dissociation of phenotypic integration in a genetically accommodated trait. Evolution & Development 10: 690-699 (2008).

Nijhout, HF. Size matters (but so does time), and It's OK to be different. Developmental Cell 15: 491-492 (2008).

Nijhout HF, Reed M, Ulrich C. Mathematical models of one-carbon metabolism. Vitamins and Hormones 79: 45-82 (2008).

Ulrich CM, Reed MC, Nijhout HF. Modeling folate, one-carbon metabolism, and DNA methylation. Nutrition Reviews 8: S27-S30 (2008).

Ulrich CM, Neuhouser M, Liu A, Boynton A, Gregory JF, Shane B, James SJ, Reed MC, Nijhout HF. Mathematical modeling of folate metabolism: Predicted effects of genetic polymorphisms on mechanisms and biomarkers relevant to carcinogenesis. Cancer Epidemiology Biomarkers & Prevention 17: 1822-1831 (2008).

Reed MC, Thomas R, Pavisic J, Nijhout HF, James SJ, Ulrich CM. A mathematical model of glutathione metabolism. Theoretical Biology and Medical Modelling 5(8): doi:10.1186/1742-4682-5-8 (2008).

Nijhout, HF. Developmental phenotypic landscapes. Evolutionary Biology 35: 100-103 (2008).

Suzuki Y, Nijhout HF. Genetic basis of adaptive evolution of a polyphenism by genetic accommodation. Journal of Evolutionary Biology 21: 57-66 (2008).

Nijhout HF, Reed MC. A mathematical model for the regulation of juvenile hormone titers. J. Insect Physiology 54: 255-264 (2008).

Leduc, D., Escartin, F., Nijhout, HF., Reed, MC., Liebl, U., Skouloubris, S. and Myllykallio, H. Flavin-dependent thymidylate synthase ThyX activity: Implications for the folate cycle in bacteria. J. Bacteriol. 189: 8537-8545 (2007).

Reed RD, Chen PH, and Nijhout, HF. Cryptic variation in butterfly eyespot development: the importance of sample size in gene expression studies. Evolution & Development 9: 2-9 (2007).

Nijhout, HF, Smith, WA. Schachar, I, Subramanian, S., Tobler, A. and Grunert, LW. The control of growth and differentiation of the wing imaginal disks of Manduca sexta. Developmental. Biology 302: 569-576 (2007).

Shingleton, A.W., Frankino, W.A., Flatt, T., Nijhout, H.F. and Emlen, D.J. Size and shape: the developmental regulation of static allometry in insects. BioEssays 29: 536-548 (2007).

Brandon, RN. and Nijhout, HF. The empirical non-equivalence of genic and genotypic models of selection: A decisive refutation of genic selectionism and pluralistic genic selectionism. Philosophy of Science 73: 277-297 (2007).

Bowsher, JH. and Nijhout, HF. Evolution of novel abdominal appendages in a sepsid fly from histoblasts, not imaginal discs. Evolution & Development 9: 347-354 (2007).

Anderson, D., Mattingly, J., Nijhout, HF., and Reed, MC. Propagation of fluctuations in biochemical systems, I. Linear SSC networks. Bull. Math. Biol. 69: 1791-1813 (2007).

Nijhout, HF., Reed, MC. and Ulrich, CM. A day in the life of cell metabolism. Biological Theory 2(2): 124-127. (2007) .

Suzuki, Y. and Nijhout, HF. Evolution of a polyphenism by genetic accommodation. Science, 311: 650-652 (2006).

Nijhout, HF., Reed, MC., Anderson, D., Mattingly, J., James, SJ., and Ulrich, CM. Long-range allosteric interactions between the folate and methionine cycles stabilize DNA methylation rate. Epigenetics. 1: 81-87 (2006).

Boyles, A.L. Billups, A.V., Deak, K.L., Siegel, D.G., Mehltretter, L., Slifer, S.H. Bassuk, A.G., Kessler, J.A., Reed, M.C. Nijhout, H.F. George, T.M., Enterline, D.S., Gilbert, J.R., Speer, M.C., and the NTD Collaborative Group. Neural tube defects and folate pathway genes: family-based association tests of gene–gene and gene–environment interactions. Environ. Health Perspect. 114: 1547-1552 (2006).

Reed, M.C., Nijhout, H.F., Neuhouser, M.L., Gregory J.F. III., Shane, B., James, S.J., Boynton, A. and Ulrich, C.M. A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism. J. Nutr. 136: 2653-2661 (2006).

Ulrich , C.M., Nijhout , H.F. and Reed, M.C. Mathematical modeling: epidemiology meets systems biology. Cancer Epidemiol. Biomarkers Prev. 15: 827-829 (2006).

Veitia, R. and Nijhout, H.F. The robustness of the transcriptional response to alterations in morphogenetic gradients. BioEssays 28: 282-289 (2006).

Nijhout, H.F., Davidowitz, G. and Roff, D.A. A quantitative analysis of the mechanism that controls body size in Manduca sexta. Journal of Biology 5: 1-16 (2006).

Nijhout,HF. Stochastic gene expression: dominance, thresholds and boundaries., in Dominance and Haploinsufficiency, edited by Veitia, R.A. (2006), pp. 61-75, Landes Press .

Nijhout HF, Reed MC, Lam S-L,Shane B, Gregory JF, and Ulrich CM. In silico experimentation with a model of hepatic mitochondrial folate metabolism. Theoretical Biology and Medical Modelling 3: 40ff (2006).

Davidowitz, G. Roff, D.A. and Nijhout, H.F. A physiological perspective on the response of body size and development time to simultaneous directional selection. Integrative and. Comparative Biology 45: 525-531 (2005).

Edgar BA, Nijhout,HF. Growth and cell cycle control in Drosophila. In: Cell Growth: Control of Cell Size, Cold Spring Harbor Monographs, edited by M.N. Hall, M.Raff and G. Thomas (2004), pp. 23-83, Cold Spring Harbor Laboratory Press .

Yang AS, Martin CH, Nijhout HF. Geographic variation of caste structure among ant populations. Current Biology 14: 514-519 (2004).

Moczek AP, Nijhout HF. Trade-offs during the development of primary and secondary sexual traits in a horned beetle. American Naturalist 163: 184-191 (2004).

Davidowitz G, D'Amico LJ, Nijhout HF. The effects of environmental variation on a mechanism that controls insect body size. Evolutionary Ecology Research 6: 49-62 (2004).

Nijhout HF, Reed MC, Budu P, and Ulrich CM. A mathematical model of the folate cycle: New insights into folate homeostasis. Journal of Biological Chemistry 279: 55008-55016 (2004).

Reed, M.C., Nijhout, H.F., Sparks, R. and Ulrich, CM. A mathematical model of the methionine cycle. J. Theoret. Biol. 226: 33-43 (2004).

Nijhout, H.F. and Davidowitz, G. Developmental perspectives on phenotypic plasticity, canalization, and fluctuating asymmetry. In: Developmental Instability: Causes and Consequences, edited by M. Polak (2003), pp. 3-13, MIT Press .

Nijhout, HF. Polymorphic mimicry in Papilio dardanus: mosaic dominance, big effects and origins. Evolution & Development 5: 579-592 (2003).

Nijhout, H.F., Maini, P.K., Madzvamuse, A., Wathen, A. and Sekimura, T. Pigmentation pattern formation in butterflies --Experiments and models. Comptes Rendus Biologies 328: 717-727 (2003).

Wheeler, D.E. and Nijhout, H.F. A perspective for understanding the modes of juvenile hormone action as a lipid signaling system. BioEssays 25: 994-1001 (2003).

Nijhout, HF.On the association between genes and complex traits. J. Invest. Dermatol. 8: 162-163 (2003).

Nijhout, HF. The control of body size in insects. Developmental Biology 261: 1-9 (2003).

Nijhout, HF.The importance of context in genetics. American Scientist 91: 416-423 (2003).

Nijhout HF, Berg AM, and Gibson WT. A mechanistic study of evolvability using the mitogen activated protein kinase cascade. Evolution & Development 5: 281-294 (2003).

Moczek, A.P. and Nijhout, H.F. Rapid evolution of a polyphenic threshold. Evolution & Development 5: 259-268 (2003).

Nijhout, HF. The development and evolution of adaptive polyphenisms. Evolution & Development 5: 9-18 (2003).

Davidowitz, G., D’Amico. L.J. and Nijhout, H.F. Critical weight in the development of insect body size. Evolution & Development. 5: 188-197 (2003).

Nijhout, HF.The control of growth. Development 130: 5863-5867 (2003).

Nijhout, HF. Gradients, diffusion and genes in pattern formation, in Origination of Organismal Form, edited by G. Müller and S. Newman, (2003), MIT Press .

Koch, PB. and Nijhout, HF. The role of wing veins in colour pattern development in the butterfly Papilio xuthus (Lepidoptera: Papilionidae). European Journal of Entomology 99: 67-72 (2002).

Nijhout, HF.The nature of robustness in development. BioEssays. 24: 553-563 (2002).

Nijhout, HF. Genetic regulatory networks. In: Encyclopedia of Evolution. (2002), Oxford University Press.

Nijhout, H.F. and Grunert, L.W. Bombyxin is a growth factor for wing imaginal disks in Lepidoptera. Proc. Nat. Acad. Sci. 99: 15446-15450 (2002).

Nijhout, H.F. and Davidowitz G. Developmental perspectives on phenotypic plasticity, canalization, and fluctuating asymmetry. In: Developmental Instability: Causes and Consequences, edited by M. Polak (2002), Oxford University Press .

Moczek, AP and Nijhout, HF.Developmental mechanism of threshold evolution in a polyphenic beetle. Evolution & Development 4: 252-264 (2002).

Nijhout, HF. The ontogeny of phenotypes. In: Cycles of Contingency, pp.129-140, edited by S oyama, P Griffiths and R Gray (2001), MIT Press .

Moczek, AP and Nijhout, HF. A method for sexing third instar larvae of the genus Onthophagus Latreille (Coleoptera Scarabeidae). Coleopt. Bull. (2001) .

Nijhout, HF. Origin of butterfly wing patterns. In: The Character Concept in Evolutionary Biology, pp.511-529, edited by GA Wagner (2001), Academic Press .

Gilchrist, MA and Nijhout, HF. Non-linear developmental processes as sources of dominance. Genetics 159: 423-432 (2001).

Shafiei, M, Moczek AP, and Nijhout HF. Food availability controls the onset of metamorphosis in the dung beetle Onthophagus taurus (Cleoptera: Scarabeidae). Physiol. Entomol. 26: 173-180 (2001).

Emlen, DJ and Nijhout, HF. Hormonal control of horn length dimorphism in Onthophagus taurus (Coleoptera: Scarabeidae): a second critical period of sensitivity to juvenile hormone. J. Insect Physiol. 47: 1045-1054 (2001).

Browder, MH, D'Amico LJ and Nijhout, HF. The role of low levels of juvenile hormone esterase in the metamorphosis of Manduca sexta. J. Insect Science 1(11): 1-5 (2001).

D' Amico, LJ, Davidowitz, G. and Nijhout, HF. The developmental and physiological basis of body size evolution in an insect. Proc. Roy. Soc. London, B, 268: 1589-1593 (2001).

McDonald, AK and Nijhout, HF. The effect of environmental conditions on mating activity of the Buckeye butterfly, Precis coenia. J. Res. Lepidopt. 35: 22-28 (2000) .

Emlen, DJ and Nijhout, HF. The development and evolution of exaggerated morphologies in insects. Annual Review of Entomology 45: 661-708 (2000).

Miner, AL, Rosenberg, AJ and Nijhout, HF. Control of growth and differentiation of the wing imaginal disks of Precis coenia (Lepidoptera: Nymphalidae). J. Insect Physiol.. 46: 251-258 (2000).



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Biology Department
Duke University