We study nutritional control of development in the model system Caenorhabditis elegans. Life in the wild is characterized by feast or famine for this free-living roundworm, and it has remarkable abilities to modify its development in response to environmental conditions. We are interested in the signaling pathways and gene regulatory mechanisms that enable the worm to reversibly arrest development and resist stress in response to starvation. We are also interested in epigenetic mechanisms that mediate transgenerational effects of starvation.